Wolves travel to Espanyol for the second leg of their UEFA Europa League Round of 32 tie at Estadi Cornellà-El Prat.
Manchester United welcome Club Brugge to Old Trafford in their UEFA Europa League Round of 32 second leg tie.
Arsenal welcome Olympiacos to the Emirates in the second leg of their UEFA Europa League Round of 32 tie.
Celtic welcome Copenhagen to Celtic Park in the second leg of their UEFA Europa League Round of 32 tie.
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Relegation-battling Norwich City face a tough test as they welcome top four-chasing Leicester City to Carrow Road in Friday Night Football from the Premier League.
Coventry City take on Sunderland at the St Andrew's Trillion Trophy Stadium in the Sky Bet Championship. A last-minute strike saw the Black Cats win 2-1 earlier in the season.
Brighton host rivals Crystal Palace at the AMEX Stadium as they meet in the Premier League.
Hull City welcome Marcelo Bielsa's Leeds United to the KCOM Stadium in the Sky Bet Championship. The Whites were 2-0 winners when the sides met earlier in the season.
Nigel Pearson's Watford welcome title-chasing Liverpool to Vicarage Road in the Premier League. A Mohamed Salah brace was enough to see the Reds over the lines in the reverse game.
Carlo Ancelotti's Everton take on Manchester United at Goodison Park in the Premier League. The sides shared the spoils in a 1-1 draw in the reverse fixture.
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The Six Nations is up and running again as Ireland take on Italy in Dublin with Ireland looking to get back to winning ways after their loss to England last time out
England meet Wales at Twickenham looking to claim the Triple Crown and keep in the running for the Six Nations Championship, Can Wales bounce back from defeat against France to spoil the England party?
A pivotal match in this years Six Nations as France travel to Edinburgh to take on Scotland. Can France take another step to the Grand Slam or will the Scots claim their second win in this years championship?
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